Table of Contents

PART A: CHRONIC FATIGUE SYNDROME: CURRENT CONCEPTS
PART I:  EPIDEMIOLOGY OF C.F.S.
PART II:  CLINICAL AND MULTIDISCIPLINARY RESEARCH ON C.F.S.
PART III:  VIRAL STUDIES OF C.F.S.
PART IV:  IMMUNOLOGIC STUDIES OF C.F.S.
PART V:  PUBLIC POLICY AND C.F.S.: A PERSPECTIVE
PART VI:  CLOSING REMARKS
 

Introduction -- Paul H. Levine

Reflections on Epidemic Neuromyasthenia (CFS) -- D.A. Henderson

Discussion: Reflections on Epidemic Neuromyasthenia (CFS)

Comments on CFS -- Alexis Shelokov
 

Introduction -- Walter J. Gunn

A Comparison of Case Definitions of CFS -- David Bates, DedraBuchwald, Joshua Lee, Phalla Kith, Teresa Doolittle, Phoebe Umali and Anthony Komaroff

Epidemic Neuromyasthenia and CFS: Epidemiological Importance of a Cluster  Definition -- Paul Levine

Primary Juvenile Fibromyalgia Syndrome and CFS in Adolescents --David Bell, Karen Bell and Paul Cheney

Borrelia burgdorferi Reactivity in Patients with Severe PersistentFatigue Who Are from a Region in Which Lyme Disease Is Endemic --P.K. Cole, Lauren Krupp, Carol Doscher and Komal Amin

CFS and a Disorder Resembling Sjogren's Syndrome: Preliminary Report -- Leonard Calabrese, Mark Davis and William Wilke

A Comparative Review of Systemic and Neurological Symptomatologyin 12 Outbreaks Collectively Described as CFS, EpidemicNeuromyasthenia and Myalgic Encephalomyelitis -- Nathaniel Briggs and Paul Levine

Concurrent Sick Building Syndrome and CFS: EpidemicNeuromyasthenia Revisited -- Alexander Chester and Paul Levine

An Approach to Studies of Cancer Subsequent to Clusters of CFS:Use of Data from the Nevada State Cancer Registry --Paul Levine, Martin Atherton, Thomas Fears and Robert Hoover

CFS: A Possible Delayed Hazard of Pesticide Exposure -- P.O. Behanand B.A.G. Haniffah

Estimating CFS-Related Symptoms Among Nurses: A Preliminary Report-- Leonard Jason, Stephanie Taylor, Sharon Johnson, Stephen Goldston,Doreen Salina, Peter Bishop and Lynne Wagner

Closeness of Contacts Between People in Two Clusters of CFS:Evidence for an Infectious Etiology? -- Seymour Grufferman, RoslynStone, Nancy Eby, Mary Huang, Susan Muldoon and Lili Penkower

Results of an Investigation of Three Clusters of CFS -- Seymour Grufferman, Paul Levine, Nancy Eby, Susan Muldoon, Mary Huang,Theresa Whiteside, Lili Penkower and Ronald Herberman

Summary and Perspective: Epidemiology of CFS -- Paul Levine

Introduction -- James Jones

Acylcartinine Deficiency in CFS -- Hirohiko Kuratsune, KouziYamaguto, Mamoru Takahashi, Hideo Misaki, Shinichi Tagawa and TeruoKitani

Sleep Disorders in Patients with Chronic Fatigue -- DedraBuchwald, Ralph Pascualy, Charles Bombardier and Phalla Kith

Psychosocial Correlates of Illness Burden in CFS -- Michael Antoni, Andrew Brickman, Susan Lurgendorf, Nancy Klimas, Ann Imia-Fins, Gail Ironson, Ruth Quillian, Maria Jose Miguez, Flavia vanRiel, Robert Morgan, Roberto Patarca and Mary Ann Fletcher

Measuring the Functional Impact of Fatigue: Initial Validation oftheFatigue Impact Scale -- John Fisk, Paul Ritvo, Lynn Ross, David Haase, Thomas Marrie and Walter Schlech

Cognitive Functioning of Patients with CFS -- Susan Johnson, John DeLuca, Nancy Fiedler and Benjamin Natelson

Laboratory Abnormalities in Patients with CFS -- DW Bates, DBuchwald, J Lee, T Doolittle, J Kornish, C Rutherford, WH Churchill,P Schur, D Wybenga, J Winkelman and AL Komaroff

Comparison of the Psychiatric and Psychological Profiles of Patients with CFS, Multiple Sclerosis, and Major Depression -- CMPepper, C Doscher, M Hirsh, E Guadino, PK Coyle and LB Krupp

Survey of the Ocular Manifestations of Chronic Fatigue ImmuneDysfunction Syndrome -- Walter Potaznick and Neil Kozol

A Controlled Clinical Trial with a Specifically Configured RNADrug, Poly(I)-Poly(C12U), in CFS -- David Strayer, William Carter,Isadore Brodsky, Paul Cheney, Daniel Peterson, Patricia Salvato,Carol Thompson, Mark Loveless, David Shapiro, William Elsasser and David Gillespie

Upregulation of the 2-5A Synthetase/RNase L Antiviral Pathway Associated with CFS -- Robert Suhadolnik, Nancy Reichenbach, PatriciaHitzges, Robert Sobol, Daniel Peterson, Berch Henry, Dharam Ablashi,Werner Muller, Heinz Schroder, William Carter and David Strayer

A Comparison of Cognitive Behavioral Treatment for CFS and Primary Depression -- Fred Friedberg and Lauren Krupp

A Pilot Study of Sertraline for the Treatment of CFS -- PO Behan, BAG Haniffah, DP Doogan and M Loudon

"One Stop Treatment"  A British Fatigue Clinic -- Simon Hatcher

A Controlled Trial of Immunologic and Cognitive-Behavioral Therapy for Patients with CFS -- Andrew Lloyd, Ian Hickie, Alan Brockman,Catherine Hickie, Andrew Wilson, John Dwyer and Denis Wakefield

Kutapressin Inhibits In Vitro Infection of Human Herpesvirus Type 6 -- DV Ablashi, Z Berneman, C Lawyer and A Komaroff

Poly(I)-Poly(C12U) Inhibits In Vitro Replication of HumanHerpesvirus Type6 -- DV Ablashi, Z Berneman, DR Strayer, RJSuhadolnik, Nancy Reichenbach, Patricia Hitzges and A Komaroff

Subjective Reduction in Symptoms of CFS Following Long-TermTreatment with a Porcine Liver Extract: A Phase 1 Trial -- Thomas Steinbach, William Hermann, Carl Lawyer, David Montefiore, SudhakarWagle, Ali Gawish and David Ferguson

Summary: Clinical and Multidisciplinary Research on CFS -- DedraBuchwald, James Jones and Paul Levine
 

Introduction: Jay Levy

Lack of Evidence for Infection with Known Human and Animal Retroviruses in Patients with CFS -- Walid Heneine, Toni Woods,Saswati Sinha, Ali Khan, Louisa Chapman, Lawrence Schonberger andThomas Folks

Studies on Enteroviruses in Patients with CFS -- JW Gow, WMH Behan, K Simpson, F McGarry, S Keir and PO Behan

Summary: Viral Studies of CFS -- Dharam Ablashi
 

Introduction -- Andrew Lloyd

Immunologic Abnormalities Associated with CFS -- Edward Barker, Sue Fujimura, Mitchell Faden, Alan Landay and Jay Levy

Cytokine Production and Fatigue in Patients with CFS and Healthy Control Subjects in Response to Exercise -- Andrew Lloyd, SimonGandevia, Alan Brockman, John Hales and Denis Wakefield

Dysregulated Expression of Tumor Necrosis Factor in CFS:Interrelations with Cellular Sources and Patterns of Soluble ImmuneMediator Expression -- Roberto Patarca, Nancy Klimas, SusanLugtendorf, Michael Antoni and Mary Ann Fletcher

Association Between HLA Class II Antigens and the Chronic Fatigue Immune Dysfunction Syndrome -- RH Keller, JL Lane, N Klimas, WMReiter, MA Fletcher

Decreased Natural Killer Cell Activity Is Associated with Severityof Chronic Fatigue Immune Dysfunction Syndrome -- Emmanual Ojo-Amaize, Edward Conley and James Peter Summary: Immunologic Studies of CFS --Andrew Lloyd and NancyKlimas

 The Economic Impact of CFS -- Andrew Lloyd and Howard Pender

Summary of Public Policy and CFS: A Perspective -- Mark Loveless, Andrew Lloyd and Rudy Perpich

CFS: What Have We learned and What Do We Need to Know? -- A L Komaroff and Nancy Klimas

Proceeding Published: The journal Clinical Infectious Diseases, Volume 18, Supplement 1, January 1994