NCF Medical Discoveries

Affecting the Worldwide CFIDS Community, One Patient at a Time

New mouse model developed for Parainfluenza Virus-5 by Northwestern University researchers (10/07)

Scientists create new animal model for Parainfluenza Virus-5 infection - A synopsis (12/07)

NCF News Release about the Homeland Security Initiative announcement regarding Parainfluenza Virus-5 (PIV-5) including a pdf file of the Homeland Security Initiative website content. (9/20/07)

"Mumps virus-induced alterations in cellular excitability during persistent infections" by Ziegler describes the role of persistent mumps virus infections in chronic neurological and/or mental disease. (9/20/07)

"Loss of functional voltage-gated sodium channels in persistent mumps virus-infected PC12 cells" by Stauffer provides proof that cells persistently infected with mumps virus were found to directly alter voltage-gated sodium channels. These findings are consistent with Parainfluenza Virus-5 (PIV-5), a rubulavirus related to mumps, and the alterations to the sodium ion channel. (9/20/07)

NCF Research Synopsis July 2007 (PDF file format)

It Is What It Is: Searching for Truth — The NCF's report on important keynote medical discrepancies regarding a severe B-cell immunodeficiency in CFIDS/ME patients. (2006)
Click here for PDF version.

Excerpt from Hillary Johnson's Osler's Web: Inside the Labyrinth of the Chronic Fatigue Syndrome Epidemic (PDF file format)

Annals of Internal Medicine article "A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus Type 6 Infection"
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The European Medical Journal Arzneimittelforschung's article "Clinical Activity of Folinic Acid in Patients with Chronic Fatigue Syndrome" which describes a high incidence of severe B-cell immunodeficiency and chronic reactivated Epstein-Barr virus (EBV) infection in patients with chronic fatigue syndrome. (PDF file format)

Journal of Clinical Microbiology article "Immunologic Abnormalities in Chronic Fatigue Syndrome" by Nancy Klimas, MD et al. (PDF file format)

The Press Release and explanatory NCF Paper are provided in both text format and printable PDF.

The subsequent titles are links to the supporting documentation referenced in the paper. Click each title to view the full document.

Note:  If you do not have Acrobat Reader installed, click the icon on the bottom of the page to download the free Acrobat Reader software.

Potential animal (zoonotic) virus identified in patients with Chronic Fatigue Syndrome, Multiple Sclerosis and Epilepsy NCF Press Release (2006)
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Parainfluenza Virus-5: A new paradigm and a serious host challenge NCF Paper (2006)
Click here for the PDF version.

A novel virus (Cryptovirus) within the rubulavirus genus and uses therefor Patent.  Dr. Steven Robbins' discovery on new virus in CFIDS, MS, and epilepsy.  Patent (2002)  (PDF file format)

Various informational press releases from Global Medical Technologies (2004) (PDF file format)

Porcine parainfluenza virus 2 discovery by scientists at Bayer AG Patent (1999) (PDF file format)

Isolation of a cytopathogenic virus from a case of porcine reproductive and respiratory syndrome (PRRS) and its characterization as parainfluenza virus type 2 Archives of Virology (1998) (PDF file format)

Nucleotide sequence for Cryptovirus fusion protein identified as a porcine rubulavirus Patent (2003) (PDF file format)

Cryptovirus fusion sequence returns 100% match for fusion protein for SER strain of porcine parainfluenza virus BLAST program, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health (2004) (PDF file format)

Nucleotide sequence for the fusion protein of porcine parainfluenza virus strain SER National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health (2003) (PDF file format)

Porcine parainfluenza virus strain SER sequence doesn't return match for the Cryptovirus fusion sequence though it is a 100% match BLAST program, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health (2004) (PDF file format)

Methods for diagnosis and treatment of chronic immune diseases; Stat-1 deficiency discovery in CFIDS (2003) Patent (PDF file format)

Viral mechanisms of immune evasion Immunology Today review paper (2000) (PDF file format)

Silencing STATs: Lessons from paramyxovirus interferon evasion Cytokine and Growth Factors review paper(2004) (PDF file format)

The V protein of Simian Virus 5 inhibits interferon signaling by targeting STAT1 for proteasome-mediated degradation Journal of Virology(1999) (PDF file format)

Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures Journal of General Virology (2000) (PDF file format)

Risk factors associated with Chronic Fatigue Syndrome in a cluster of pediatric cases Reviews of Infectious Diseases (1991) (PDF file format)

Relationships and host range of human, canine, simian and porcine isolates of simian virus 5 (parainfluenza virus 5) Journal of General Virology (2004) (PDF file format)

In vitro identification and characterization of a virus isolated from a dog with neurological dysfunction Infection and Immunity (1981) (PDF file format)

Potential role of persistent paramyxovirus infection in Chronic Fatigue Syndrome Interim progress report and research proposal (2005) (PDF file format)

Related Research:

Molecular Structure Of Viral Protein, Parainfluenza Virus 5 Fusion (F) Protein, Identified By Scientists At Northwestern University Medical News Today article (2006)

Other:

Hemispherx Biopharma VS R.E.D. Laboratories — US District Court Filed 1/10/2005 (PDF file format)