NCF-funded Research

Note: If you are a CFIDS/ME patient who will be undergoing surgery, you can further research by donating samples taken during surgery. Click here for more information.

The National CFIDS Foundation has contributed funds towards the following research studies:

Field of study
Ciguatera Toxicology
General
Immunology
Infectious Disease
Neurology
Radiation
Virology
Other Related Scientific Research Not Directly Funded by the NCF

Ciguatera Toxicology

• The Role of Blue-Green Algal Toxins in the Development of Alzheimer's, Parkinson's, ALS (Lou Gehrig's Disease), and Cancers
  The Nancy Taylor Foundation for Chronic Diseases (Oct 2009) (PDF file)
  
  
• Ciguatera testing protocol
  Please note that there is currently a hold on testing
  (Sep 2009) (PDF file)
  
  
• Antileukemia activity from root cultures of Vernonia amygdalina
  Journal of Medicinal Plants Research (July 2009) (PDF file)
  
  
• Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome
  J Clin Lab Anal. (2009) (PDF file)
  
  
• Ciguatera epitope is autoimmune marker
  (2008) (PDF file)
  
  
• Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX.
  J Clin Lab Anal. (2003) (PDF file)
  
  
• Chronic phase lipids in sera of several chronic diseases reacting with MAb-CTX (antibody to ciguatoxin)
  Journal of Toxicology: Toxins Review (2003) (PDF file)
  
  
• Ciguatera Toxin FAQ
  (2003; 2005)
  
  
• The Ciguatera Epitope: So What Do We Really Know Thus Far?
  Forum newsletter (2003)
  
  
• Presentation given by Dr. Yoshitsugi Hokama at the International Symposium on Toxins and Natural Products
  (2002) (PDF file)
  
  
• Neurotoxin Discovered in Chronic Fatigue Syndrome
  (Press release: 2002)
  
  
• The Neurology of ciguatera
  J Neurol Neurosurg Psychiatry (2001)
  Can be viewed as a PDF or Text file

General

• Polygenic Contributions of Procoagulant Genetic Factors in Chronic Fatigue Syndrome and Related Chronic Illnesses
  Genetics in Medicine (2002)
  
  
• Activation of the coagulation system in Gulf War Illness: a potential pathophysiologic link with chronic fatigue syndrome. A laboratory approach to diagnosis
  Blood Coagul Fibrinolysis (2000)

Immunology

• Dr. Konstance Knox Presents STAT1 Data to Researchers and Clinicians at AACFS Conference
  AACFS Conference (2004)
  
  
• STAT1-alpha and p53 Deficiencies Are Found In Patients With Chronic Fatigue Syndrome
  Forum newsletter (2003)
  
  
• Expanded Model for RNase L Fragmentation in CFS Uncovered; The National CFIDS Foundation Announces The Use Of Elastase Inhibitors as a Potential Treatment for CFS Inovations
  Forum newsletter (2003)

Click here for the above 2 articles together in printable PDF file format.

• Potential Role of STAT1 in the Pathogenesis of Chronic Fatigue Syndrome
  Institute for Viral Pathogenesis (2003)

Infectious Disease

• The National CFIDS Foundation has provided its latest research grant funding to Grieg Steward, Ph.D. for his grant titled "Testing for the presence of vibrio bacteria in clinical samples from CFIDS patients."
  (June 6 2012)
  
  
• Persistent Active Human Herpesvirus Six (HHV-6) Infections In Patients With Chronic Fatigue Syndrome
  AACFS Conference (1998)

Neurology

• The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome
  Am J Med Sci (2000)
  
  
• Circulating blood volume in chronic fatigue syndrome
  Journal of Chronic Fatigue Syndrome (1998)

Radiation

• Radiation Research
  In this publication, Drs. Mothersill and Seymour show that radiation induced bystander mechanisms are more complex than previously expected and caution should be taken when extrapolating bystander results across all cell lines and all radiation doses. This research was funded by the NCF.
  
  

Virology

• Potential animal (zoonotic) virus identified in patients with Chronic Fatigue Syndrome, Multiple Sclerosis and Epilepsy
  (NCF Press Release: 2006) Click here for the PDF version.
  
  
• Parainfluenza Virus-5: A new paradigm and a serious host challenge
  NCF Paper (2006) Click here for the PDF version.
  
  
• Potential role of persistent paramyxovirus infection in Chronic Fatigue Syndrome
  Interim progress report and research proposal (2005) (PDF file)

Other Related Scientific Research Not Directly Funded by the NCF:

• Okadaic acid-like toxin in systemic lupus erythematosus patients: hypothesis for toxin-induced pathology, immune dysregulation, and transactivation of herpesviruses
  Medical Hypotheses (1996) (PDF file)
  
  
• A chronic fatigue syndrome-related proteome in human cerebrospinal fluid
  BMC Neurology (2005) (PDF file format
  
  
• Mitochondrial Dysfunction in Chronic Fatigue Syndrome
  (PDF file)